Another filler episode, but I actually thought a lot of it worked quite well.
Sam and Dean are on the case after three people commit suicide by gutting themselves. Dean meets a nun, Sister Mathias, at the church who tells him that all three of the victims had recently been to confession. Sam and Dean aren't sure what's going on, so Dean decides to go to confession to see if there's a curse or a ghost or something else like that. In his confession, Dean starts by just talking about his exploits with the ladies, but then after some prodding he admits that he doesn't want to die. He wants to experience things in a new way, and maybe feel a deeper connection with someone.
Throughout the episode, a nun working at the church talks with another nun, a woman named Isabella who has a terrible story. She was in love with a great artist in Italy, but the artist did not love her back. As she saw him with another man, she decided to kill him. It is revealed later on that this woman is actually a ghost from the 1500s. Sister Mathias comes clean to Sam and Dean that she knew about the ghost. She says she didn't know that Isabella was hurting anybody, because a lot of ghosts end up hanging out around the church for a while. Mostly they are harmless.